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Exp Clin Endocrinol Diabetes 2013; 121(02): 91-93
DOI: 10.1055/s-0032-1327757
Short Communication
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Ropivacaine Infusion in Diabetics Subject with Peripheral Arterial Disease. A Prospective Study

M.N. D. Di Minno   *
1   Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples
,
M. Milone   *
2   Department Of General Surgery, Federico II University, Naples
,
A. Russolillo
1   Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples
,
R. Lupoli
1   Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples
,
A. Di Minno
1   Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples
,
P. Maietta
2   Department Of General Surgery, Federico II University, Naples
,
C. Iacovazzo
3   Department Of Anesthesiology, Federico II University, Naples
,
G. Salvatore
2   Department Of General Surgery, Federico II University, Naples
,
F. Milone
2   Department Of General Surgery, Federico II University, Naples
› Author Affiliations
Further Information

Publication History

received 04 June 2012
first decision 05 October 2012

accepted 17 October 2012

Publication Date:
12 November 2012 (online)

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Abstract

Background:

Peripheral arterial disease (PAD) predicts cardiovascular and cerebrovascular ischemic events. PAD treatment is aimed at reducing clinical symptoms, local tissue loss and at preventing complications.

Aims:To evaluated the effect of peridural analgesia on peripheral perfusion and pain control.

Methods:

In 280 diabetic subjects with severe limb ischemia (65.7% males and 34.3% females, mean age 59.3±14.4 years) with a failure of medical treatment and contraindications to endovascular and/or surgical reperfusion, we performed a 30-day long peridural ropivacaine infusion, monitoring blood pressure, VAS and ABI periodically.

Results:

During ropivacaine infusion VAS significantly decreased (from 4.06±0.343 to 1.96±0.413, p<0.001). Furthermore, in the 261 (93.2%) subjects achieving a VAS value≤2 during infusion, the effect was maintained after infusion withdrawing. ABI significantly improved both during infusion (from 0.30±0.04 at baseline to 0.65±0.05 at T30, p<0.001) and after infusion withdrawing as compared with baseline values.

Conclusions:

30-day peridural analgesia with ropivacaine is a valuable therapeutic option in severe peripheral limb ischemia subjects with contraindication to surgery and with pharmacological therapy failure.

Keywords

peripheral arterial disease - Diabetes - cardiovascular risk management
*

*  The 2 authors equally contributed to this study.


 

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