Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Kindes- und Jugendalter

A. Neu; P. Beyer; J. Bürger-Büsing; T. Danne; J. Etspüler; B. Heidtmann; R. W. Holl; B. Karges; W. Kiess; I. Knerr; O. Kordonouri; K. Lange; R. Lepler; W. Marg; A. Näke; M. Petersen; A. Podeswik; R. Stachow; S. von Sengbusch; V. Wagner; R. Ziegler; P. M. Holterhus

doi:10.1055/s-0032-1325581

Diabetologie und Stoffwechsel, Inhaltsverzeichnis

Diabetologie und Stoffwechsel 2012; 7: S152-S162
DOI: 10.1055/s-0032-1325581

DDG Praxisempfehlung

Diagnostik, Therapie und Verlaufskontrolle des Diabetes mellitus im Kindes- und Jugendalter

A. Neu¹ , P. Beyer² , J. Bürger-Büsing³ , T. Danne⁴ , J. Etspüler⁵ , B. Heidtmann⁶ , R. W. Holl⁷ , B. Karges⁸ , W. Kiess⁹ , I. Knerr¹⁰ , O. Kordonouri¹¹ , K. Lange¹² , R. Lepler¹³ , W. Marg¹⁴ , A. Näke¹⁵ , M. Petersen¹⁶ , A. Podeswik¹⁷ , R. Stachow¹⁸ , S. von Sengbusch¹⁹ , V. Wagner²⁰ , R. Ziegler²¹ , P. M. Holterhus²²

¹Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Tübingen
²Klinik für Kinder und Jugendliche, Evangelisches Krankenhaus GmbH, ?Oberhausen
³Bund diabetischer Kinder und Jugendlicher e. V., Kaiserslautern
⁴Diabetes-Zentrum für Kinder und Jugendliche, Kinderkrankenhaus auf der Bult, Hannover
⁵Altonaer Kinderkrankenhaus gGmbH, Hamburg
⁶Kindermedizinisches Versorgungszentrum am Wilhelmstift, Hamburg
⁷Abt. Epidemiologie, Universitätsklinikum Ulm
⁸Universitäts-Kinderklinik, Aachen
⁹Universitätsklinik und Poliklinik für Kinder und Jugendliche, Leipzig
¹⁰Kinder- und Jugendklinik des Universitätsklinikums Erlangen
¹¹Diabetes-Zentrum für Kinder und Jugendliche, Kinderkrankenhaus auf der Bult, Hannover
¹²Medizinische Hochschule, Medizinische Psychologie, Hannover
¹³Katholisches Kinderkrankenhaus Wilhelmstift, Hamburg
¹⁴Klinikum Bremen-Mitte gGmbH, Zentrum für Kinderheilkunde und Jugendmedizin, Bremen
¹⁵Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Dresden
¹⁶Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck
¹⁷beta-Institut, Augsburg
¹⁸Fachklinik Sylt für Kinder und Jugendliche, Westerland
¹⁹Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck
²⁰Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck
²¹Diabetologische Schwerpunktpraxis, Münster
²²Klinik für allgemeine Pädiatrie, Universitätsklinikum Schleswig-Holstein, Campus Kiel

Abstract

Volltext

Referenzen

Literatur

1 Scherbaum W A, Kerner W. Evidenzbasierte Leitlinie der DDG – Therapie des Diabetes mellitus Typ 1. In: Martin S, Dreyer M, Kiess W, Lüdecke HJ, Müller UA, Schatz W. Deutsche Diabetes Gesellschaft (DDG) 2007
2 Neu A, Willasch A, Ehehalt S et al. Prävalenz und Altersverteilung des Diabetes mellitus im Kindesalter in Deutschland. Monatsschr Kinderheilkd. 2002; 150 196-200
3 Rosenbauer J, Icks A, Grabert M et al. Hohe Prävalenz des Typ-1-Diabetes mellitus im Kindes- und Jugendalter in Deutschland (Abstract). Kinder-Jugendmed. 2002; 2
4 Ehehalt S, Blumenstock G, Willasch A M et al. Continuous rise in incidence of childhood Type 1 diabetes in Germany. Diabet Med. 2008; 25 755-757
5 Neu A, Ehehalt S, Willasch A et al. Rising incidence of type 1 diabetes in Germany: 12-year trend analysis in children 0–14 years of age. Diabetes Care. 2001; 24 785-786
6 Rosenbauer J, Icks A, Schmitter D et al. Incidence of childhood Type I diabetes mellitus is increasing at all ages in Germany. Diabetologia. 2002; 45 457-458
7 Kurth B M, Schaffrath R A. Die Verbreitung von Übergewicht und Adipositas bei Kindern und Jugendlichen in Deutschland. Ergebnisse des bundesweiten Kinder- und Jugendgesundheitssurveys (KiGGS). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2007; 50 736-743
8 Kromeyer-Hauschild K, Wabitsch M, Kunze D et al. Perzentile für den Body-Mass-Index für das Kindes- und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilkd. 2001; 149 807-818
9 Rosenbauer J, Icks A, du Prel J B et al. Populationsbasierte Daten zur Inzidenz des Typ-2-Diabetes mellitus bei Kindern und Jugendlichen in Deutschland. Monatsschr Kinderheilkd. 2003; 151 71
10 Neu A, Feldhahn L, Ehehalt S et al. Prevalence of type 2 diabetes and MODY in children and adolescents. A state-wide study in Baden-Wuerttemberg (Germany). Pediatr Diabetes. 2005; 6 27-28
11 Australasian Paediatric Endocrine Group, Department of Health and Ageing, National Health and Medical Research Council (NHMRC) .Clinical practice guidelines: Type 1 diabetes in children and adolescents. 2005, EK IV
12 Gale E A, Gillespie K M. Diabetes and gender. Diabetologia. 2001; 44 3-15
13 Rosenbloom A L, Schatz D A, Krischer J P et al. Therapeutic controversy: prevention and treatment of diabetes in children. J Clin Endocrinol Metab. 2000; 85 494-522
14 Clinical practice guidelines: Type 1 diabetes in children and adolescents. 2005, EK I b
15 Arbeitsgemeinschaft Adipositas im Kindes- und Jugendalter (AGA) .Leit?linien. Verabschiedet auf der Konsensus-Konferenz der AGA am 06.10.2008, Deutsche Adipositas-Gesellschaft (2008)
16 Bangstad H J, Danne T, Deeb L C et al. Insulin treatment. ISPAD clinical practice consensus guidelines 2006–2007. Pediatr Diabetes. 2007; 8 88-102
17 Australasian Paediatric Endocrine Group, Department of Health and Ageing, National Health and Medical Research Council (NHMRC) .Clinical practice guidelines: Type 1 diabetes in children and adolescents. 2005, EK II b-III
18 Rewers M, Pihoker C, Donaghue K et al. Assessment and monitoring of glycemic control in children and adolescents with diabetes. Pediatr Diabetes. 2007; 8 408-418
19 Cranston I, Lomas J, Maran A et al. Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes. Lancet. 1994; 344 283-287
20 Holl R W, Heinze E. Dawn- oder Somogyi-Phänomen? Hohe morgendliche Nüchternblutzuckerwerte bei jugendlichen Typ-1-Diabetikern. Dtsch Med Wochenschr. 1992; 117 1503-1507
21 Hellems M A, Clarke W L. Safe at school: a Virginia experience. Diabetes Care. 2007; 30 1396-1398
22 American Diabetes Association (ADA). Diabetes care in the school and day care setting. Diabetes Care. 2007; 30 Suppl 1 S66-S73
23 Nakhla M, Daneman D, Frank M et al. Translating transition: a critical review of the diabetes literature. J Pediatr Endocrinol Metab. 2008; 21 507-516
24 Australasian Paediatric Endocrine Group, Department of Health and Ageing, National Health and Medical Research Council (NHMRC) .Clinical practice guidelines: Type 1 diabetes in children and adolescents. 2005
25 Court J M, Cameron F J, Berg-Kelly K et al. Diabetes in adolescence. Pediatr Diabetes. 2008; 9 255-262
26 Brink S, Laffel L, Likitmaskul S et al. Sick day management in children and adolescents with diabetes. Pediatr Diabetes. 2007; 8 401-407
27 Diabetes Control and Complications Trial Research Group . The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Diabetes. 1995; 44 968-983
28 White N H, Sun W, Cleary P A et al. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Ophthalmol. 2008; 126 1707-1715
29 Nathan D M, Cleary P A, Backlund J Y et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005; 353 2643-2653
30 Musen G, Jacobson A M, Ryan C M et al. Impact of diabetes and its treatment on cognitive function among adolescents who participated in the Diabetes Control and Complications Trial. Diabetes Care. 2008; 31 1933-1938
31 Bangstad H J, Danne T, Deeb L C et al. Insulin treatment. ISPAD clinical practice consensus guidelines 2006–2007. Pediatr Diabetes. 2007; 8 88-102
32 Danne T, Becker R H, Heise T et al. Pharmacokinetics, prandial glucose control, and safety of insulin glulisine in children and adolescents with type 1 diabetes. Diabetes Care. 2005; 28 2100-2105
33 Mortensen H B, Lindholm A, Olsen B S et al. Rapid appearance and onset of action of insulin aspart in paediatric subjects with type 1 diabetes. Eur J Pediatr. 2000; 159 483-488
34 Deeb L C, Holcombe J H, Brunelle R et al. Insulin lispro lowers postprandial glucose in prepubertal children with diabetes. Pediatrics. 2001; 108 1175-1179
35 Plank J, Siebenhofer A, Berghold A et al. Systematic review and meta-analysis of short-acting insulin analogues in patients with diabetes mellitus. Arch Intern Med. 2005; 165 337-344
36 Simpson D, McCormack P L, Keating G M et al. Insulin lispro: a review of its use in the management of diabetes mellitus. Drugs. 2007; 67 407-434
37 Danne T, Aman J, Schober E et al. A comparison of postprandial and preprandial administration of insulin aspart in children and adolescents with type 1 diabetes. Diabetes Care. 2003; 26 2359-2364
38 Danne T, Datz N, Endahl L et al. Insulin detemir is characterized by a more reproducible pharmacokinetic profile than insulin glargine in children and adolescents with type 1 diabetes: results from a randomized, double-blind, controlled trial. Pediatr Diabetes. 2008; 9 554-560
39 Thisted H, Johnsen S P, Rungby J. An update on the long-acting insulin analogue glargine. Basic Clin Pharmacol Toxicol. 2006; 99 1-11
40 Robertson K J, Schoenle E, Gucev Z et al. Insulin detemir compared with NPH insulin in children and adolescents with Type 1 diabetes. Diabet Med. 2007; 24 27-34
41 Phillip M, Battelino T, Rodriguez H et al. Use of insulin pump therapy in the pediatric age-group: consensus statement from the European Society for Paediatric Endocrinology, the Lawson Wilkins Pediatric Endocrine Society, and the International Society for Pediatric and Adolescent Diabetes, endorsed by the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2007; 30 1653-1662
42 Aslander-van Vliet E, Smart C et al. Nutritional management in childhood and adolescent diabetes. Pediatr Diabetes. 2007; 8 323-339
43 Mann J, Leeuw de I, Hermansen K et al. Evidenz-basierte Ernährungsempfehlungen zur Behandlung und Prävention des Diabetes mellitus. Diabet Stoffw. 2005; 14 75-94
44 Deutsche Gesellschaft für Ernährung (DGE), Österreichische Gesellschaft für Ernährung (ÖGE), Schweizerische Gesellschaft für Ernährungsforschung (SGE), Schweizerische Vereinigung für Ernährung (SVE). Referenzwerte für die Nährstoffzufuhr. Neustadt / Weinstraße: Neuer Umschau Buchverl.; 2008
45 Bloomgarden Z T, Karmally W, Metzger M J et al. Randomized, controlled trial of diabetic patient education: improved knowledge without improved metabolic status. Diabetes Care. 1987; 10 263-272
46 Weerdt de I, Visser A P, Kok G J et al. Randomized controlled multicentre evaluation of an education programme for insulin-treated diabetic patients: effects on metabolic control, quality of life, and costs of therapy. Diabet Med. 1991; 8 338-345
47 Lange K, Sassmann H, Schütz von W et al. Prerequisites for age-appropriate education in type 1 diabetes: a model programme for paediatric diabetes education in Germany. Pediatr Diabetes. 2007; 8 Suppl 6 63-71
48 Swift P G. Diabetes education. ISPAD clinical practice consensus guidelines 2006–2007. Pediatr Diabetes. 2007; 8 103-109
49 Mensing C, Boucher J, Cypress M et al. National standards for diabetes self-management education. Task Force to Review and Revise the National Standards for Diabetes Self-Management Education Programs. Diabetes Care. 2000; 23 682-689
50 Funnell M M, Brown T L, Childs B P et al. National standards for diabetes self-management education. Diabetes Care. 2009; 32 Suppl 1 S87-S94
51 Bundesarbeitsgemeinschaft für Rehabilitation (BAR) .Gemeinsames Rahmenkonzept der Gesetzlichen Krankenkassen und der Gesetzlichen Rentenversicherung für die Durchführung stationärer medizinischer Leistungen der Vorsorge und Rehabilitation für Kinder und Jugendliche. http://http://www.bar-frankfurt.de/upload/Rahmenkonzept.72dpi_435.pdf , 2008
52 Fröhlich C, Hermann T, Koch S et al. Indikationen für eine stationäre Rehabilitation von Kindern und Jugendlichen mit Typ-1-Diabetes – eine bundesweite „DPV-Wiss“-Analyse. Diabet Stoffw. 2008; 93
53 Verband Deutscher Rentenversicherungsträger (VDR) .Rahmenkonzept zur medizinischen Rehabilitation von Kindern und Jugendlichen in der gesetzlichen Rentenversicherung. Empfehlungen des Verbandes Deutscher Rentenversicherungsträger. http://http://infomed.mds-ev.de/sindbad.nsf/f79a8096ad98496fc12571e700442be0/3ccf1982457e68f080256bc4003b2fa3/$FILE/ATTS1QCV/VDR_KiJu-Reha_1998.pdf , 1998
54 Deutsche Gesellschaft für pädiatrische Rehabilitation und Prävention. Leitlinie Rehabilitation Diabetes mellitus im Kindes- und Jugendalter. http://http://www.uni-duesseldorf.de/awmf/ll/070–003.htm , 2007
55 Stachow R, Koch S, Fröhlich C et al. Effekte der stationären Rehabilitation von Kindern und Jugendlichen mit Diabetes mellitus Typ 1 – eine multizentrische DPV-Wiss-Analyse. Diabet Stoffw. 2008; 59
56 Stachow R, Schultz A, Kurzinsky U et al. Anti-Streß-Training für Kinder und Jugendliche mit Diabetes während der stationären Rehabilitation. Kindheit Entwicklung. 2001; 10 226-239
57 Delamater A M. Psychological care of children and adolescents with diabetes. Pediatr Diabetes. 2007; 8 340-348
58 Forsander G, Persson B, Sundelin J et al. Metabolic control in children with insulin-dependent diabetes mellitus 5 y after diagnosis. Early detection of patients at risk for poor metabolic control. Acta Paediatr. 1998; 87 857-864
59 Hürter A, Otten A. Familien mit diabetischen Kindern und Jugendlichen: Psychische und soziale Probleme und der Wunsch nach psychologischer Hilfe im Vergleich mit anderen chronischen Erkrankungen. In: Roth R, Borkenstein M, eds. Psychosoziale Aspekte in der Betreuung von Kindern und Jugendlichen mit Diabetes. Basel: Karger; 1991: 150–159
60 Sundelin J, Forsander G, Mattson S E. Family-oriented support at the onset of diabetes mellitus: a comparison of two group conditions during 2 years following diagnosis. Acta Paediatr. 1996; 85 49-55
61 Delamater A M, Bubb J, Davis S G et al. Randomized prospective study of self-management training with newly diagnosed diabetic children. Diabetes Care. 1990; 13 492-498
62 Rydall A C, Rodin G M, Olmsted M P et al. Disordered eating behavior and microvascular complications in young women with insulin-dependent diabetes mellitus. N Engl J Med. 1997; 336 1849-1854
63 Bryden K S, Neil A, Mayou R A et al. Eating habits, body weight, and insulin misuse. A longitudinal study of teenagers and young adults with type 1 diabetes. Diabetes Care. 1999; 22 1956-1960
64 Nielsen S, Emborg C, Molbak A G. Mortality in concurrent type 1 diabetes and anorexia nervosa. Diabetes Care. 2002; 25 309-312
65 Meltzer L J, Johnson S B, Prine J M et al. Disordered eating, body mass, and glycemic control in adolescents with type 1 diabetes. Diabetes Care. 2001; 24 678-682
66 Colton P, Olmsted M, Daneman D et al. Disturbed eating behavior and eating disorders in preteen and early teenage girls with type 1 diabetes: a case-controlled study. Diabetes Care. 2004; 27 1654-1659
67 Liss D S, Waller D A, Kennard B D et al. Psychiatric illness and family support in children and adolescents with diabetic ketoacidosis: a controlled study. J Am Acad Child Adolesc Psychiatry. 1998; 37 536-544
68 Northam E A, Matthews L K, Anderson P J et al. Psychiatric morbidity and health outcome in Type 1 diabetes – perspectives from a prospective longitudinal study. Diabet Med. 2005; 22 152-157
69 Hood K K, Huestis S, Maher A et al. Depressive symptoms in children and adolescents with type 1 diabetes: association with diabetes-specific characteristics. Diabetes Care. 2006; 29 1389-1391
70 Stewart S M, Rao U, Emslie G J et al. Depressive symptoms predict hospitalization for adolescents with type 1 diabetes mellitus. Pediatrics. 2005; 115 1315-1319
71 Lawrence J M, Standiford D A, Loots B et al. Prevalence and correlates of depressed mood among youth with diabetes: the SEARCH for Diabetes in Youth study. Pediatrics. 2006; 117 1348-1358
72 Australasian Paediatric Endocrine Group, Department of Health and Ageing, National Health and Medical Research Council (NHMRC) .Clinical practice guidelines: Type 1 diabetes in children and adolescents. 2005, EK III / IV
73 Glaser N S, Wootton-Gorges S L, Buonocore M H et al. Frequency of sub-clinical cerebral edema in children with diabetic ketoacidosis. Pediatr Diabetes. 2006; 7 75-80
74 Fiordalisi I, Novotny W E, Holbert D et al. An 18-yr prospective study of pediatric diabetic ketoacidosis: an approach to minimizing the risk of brain herniation during treatment. Pediatr Diabetes. 2007; 8 142-149
75 Wolfsdorf J, Craig M E, Daneman D et al. Diabetic ketoacidosis. Pediatr Diabetes. 2007; 8 28-43
76 Edge J A, Jakes R W, Roy Y et al. The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children. Diabetologia. 2006; 49 2002-2009
77 Wolfsdorf J, Craig M E, Daneman D et al. Diabetic ketoacidosis. Pediatr Diabetes. 2007; 8 28-43
78 Hanas R, Lindgren F, Lindblad B. Diabetic ketoacidosis and cerebral oedema in Sweden – a 2-year paediatric population study. Diabet Med. 2007; 24 1080-1085
79 Roberts M D, Slover R H, Chase H P. Diabetic ketoacidosis with intracerebral complications. Pediatr Diabetes. 2001; 2 109-114
80 Franklin B, Liu J, Ginsberg-Fellner F. Cerebral edema and ophthalmoplegia reversed by mannitol in a new case of insulin-dependent diabetes mellitus. Pediatrics. 1982; 69 87-90
81 Banks C J, Furyk J S. Review article: hypertonic saline use in the emergency department. Emerg Med Australas. 2008; 20 294-305
82 Clarke W, Jones T, Rewers A et al. Assessment and management of hypoglycemia in children and adolescents with diabetes. Pediatr Diabetes. 2008; 9 165-174
83 Diabetes Control and Complications Trial Research Group . Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus: Diabetes Control and Complications Trial. J Pediatr. 1994; 125 177-188
84 Bangstad H J, Danne T, Deeb L C et al. Insulin treatment. ISPAD clinical practice consensus guidelines 2006–2007. Pediatr Diabetes. 2007; 8 88-102
85 Silverstein J, Klingensmith G, Copeland K et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care. 2005; 28 186-212
86 Hill I D, Dirks M H, Liptak G S et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2005; 40 1-19
87 Silverstein J, Klingensmith G, Copeland K et al. Care of children and adolescents with type 1 diabetes: a statement of the American Diabetes Association. Diabetes Care. 2005; 28 186-212
88 Kordonouri O, Maguire A M, Knip M et al. ISPAD Clinical Practice Consensus Guidelines 2006–2007. Other complications and associated conditions. Pediatr Diabetes. 2007; 8 171-176
89 Hansen D, Brock-Jacobsen B, Lund E et al. Clinical benefit of a gluten-free diet in type 1 diabetic children with screening-detected celiac disease: a population-based screening study with 2 years‘ follow-up. Diabetes Care. 2006; 29 2452-2456
90 Amin R, Murphy N, Edge J et al. A longitudinal study of the effects of a gluten-free diet on glycemic control and weight gain in subjects with type 1 diabetes and celiac disease. Diabetes Care. 2002; 25 1117-1122
91 Lewis H M, Renaula T L, Garioch J J et al. Protective effect of gluten-free diet against development of lymphoma in dermatitis herpetiformis. Br J Dermatol. 1996; 135 363-367
92 Genuth S, Alberti K G, Bennett P et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care. 2003; 26 3160-3167
93 Alberti G, Zimmet P, Shaw J et al. Type 2 diabetes in the young: the evolving epidemic: the international diabetes federation consensus workshop. Diabetes Care. 2004; 27 1798-1811
94 UK Prospective Diabetes Study (UKPDS) Group . Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998; 352 837-853
95 Holman R R, Paul S K, Bethel M A et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008; 359 1577-1589
96 Shimazaki T, Kadowaki T, Ohyama Y et al. Hemoglobin A1c (HbA1c) predicts future drug treatment for diabetes mellitus: a follow-up study using routine clinical data in a Japanese university hospital. Transl Res. 2007; 149 196-204
97 UK Prospective Diabetes Study (UKPDS) Group . Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998; 352 854-865
98 Jones K L, Arslanian S, Peterokova V A et al. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabetes Care. 2002; 25 89-94
99 Gottschalk M, Danne T, Vlajnic A et al. Glimepiride versus metformin as monotherapy in pediatric patients with type 2 diabetes: a randomized, single-blind comparative study. Diabetes Care. 2007; 30 790-794
100 Ellard S, Bellanne-Chantelot C, Hattersley A T. Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia. 2008; 51 546-553
101 Badenhoop K, Kordonouri O, Machicao F. Empfehlungen zur molekulargenetischen Diagnostik bei Verdacht auf MODY. DDG 2008
102 Hattersley A, Bruining J, Shield J et al. ISPAD Clinical Practice Consensus Guidelines 2006–2007. The diagnosis and management of monogenic diabetes in children. Pediatr Diabetes. 2006; 7 352-360
103 Flanagan S E, Edghill E L, Gloyn A L et al. Mutations in KCNJ11, which encodes Kir6.2, are a common cause of diabetes diagnosed in the first 6 months of life, with the phenotype determined by genotype. Diabetologia. 2006; 49 1190-1197
104 Babenko A P, Polak M, Cave H et al. Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. N Engl J Med. 2006; 355 456-466
105 Klupa T, Kowalska I, Wyka K et al. Mutations in the ABCC8 gene are associated with a variable clinical phenotype. Clin Endocrinol (Oxf). 2008;
106 Lanng S, Thorsteinsson B, Lund-Andersen C et al. Diabetes mellitus in Danish cystic fibrosis patients: prevalence and late diabetic complications. Acta Paediatr. 1994; 83 72-77
107 Nousia-Arvanitakis S, Galli-Tsinopoulou A, Karamouzis M. Insulin improves clinical status of patients with cystic-fibrosis-related diabetes mellitus. Acta Paediatr. 2001; 90 515-519
108 Rolon M A, Benali K, Munck A et al. Cystic fibrosis-related diabetes mellitus: clinical impact of prediabetes and effects of insulin therapy. Acta Paediatr. 2001; 90 860-867
109 Dobson L, Hattersley A T, Tiley S et al. Clinical improvement in cystic fibrosis with early insulin treatment. Arch Dis Child. 2002; 87 430-431
110 O'Riordan S M, Robinson P D, Donaghue K C et al. Management of cystic fibrosis-related diabetes. Pediatr Diabetes. 2008; 9 338-344
111 Man S A, Andre J L, Bachmann de H et al. Blood pressure in childhood: pooled findings of six European studies. J Hypertens. 1991; 9 109-114 b

PD Dr. med. Andreas Neu

Universitätsklinikum · Klinik für Kinder- und Jugendmedizin

Hoppe-Seyler-Str. 1

72076 Tübingen

Telefon: 0 70 71 / 2 98 37 81

eMail: Andreas.Neu@med.uni-tuebingen.de