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Planta Med 2012; 78 - PL37
DOI: 10.1055/s-0032-1325179
DOI: 10.1055/s-0032-1325179
Biomimetic oxidative derivatization of ursolic acid by using 'Ru'-porphyrin for cytotoxic activity against tumor cell lines
Ursene-type pentacyclic triterpenes, including the ursolic acid 1 and a new ursene-type pentacyclic triterpene, 7,24-dihydroxyursolic acid were isolated from medicinal plant, Saurauja roxburghii. They were tested for the cytotoxicity against C6 rat glioma and A431 human skin carcinoma cell lines.. Biomimetic chemical oxidation using the “Ru”-porphyrin derivatives a-g, six ursolic acid derivatives 2-7 were isolated, their distributions and selectivity were apparently affected by the auxiliaries, a-g.