Planta Med 2012; 78 - PL36
DOI: 10.1055/s-0032-1325178

Compounds form the roots of Harpagophytum procumbens and their anti-inflammatory activity

YH Bae 1, DC To 1, SW Ryoo 2, JH Lee 2, BS Min 1
  • 1College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712–702, Korea
  • 2College of Natural Science, Kangwon National University, Kangwon 200–701, Korea

Six known compounds: cinnamic acid (1), harpagoside, (2), 8-O-(cis-cinnamoyl)harpagide (3), acteoside (4), isoacteoside (5), and 6'-O-cinnamoylharpagide (6) were isolated from the roots of Harpagophytum procumbens. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells.

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