PDF herunterladen
Am J Perinatol 2013; 30(01): 001-004
DOI: 10.1055/s-0032-1322511
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Role of Massive Transfusion Protocols in Obstetrics

Luis D. Pacheco
1   Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
2   Division of Surgical Critical Care, Department of Anesthesiology, The University of Texas Medical Branch, Galveston, Texas
,
George R. Saade
1   Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
,
Maged M. Costantine
1   Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
,
Steven L. Clark
3   Women and Newborns Clinical Program, Hospital Corporation of America, Salt Lake City, Utah
,
Gary D.V. Hankins
1   Division of Maternal–Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston, Texas
› Institutsangaben
Weitere Informationen

Publikationsverlauf

30. Januar 2012

16. März 2012

Publikationsdatum:
26. Juli 2012 (online)

   Lizenzen und Reprints

Abstract

Obstetric hemorrhage is a leading cause of maternal mortality worldwide. New concepts involving the pathophysiology of hemorrhage have been described and include early activation of both the protein C and fibrinolytic pathways. New tendencies in hemorrhage treatment include the use of hemostatic resuscitation. Massive transfusion protocols involve the early utilization of blood products and limit the traditional approach of early massive crystalloid based resuscitation. The evidence behind hemostatic resuscitation is still limited.

Keywords

obstetric hemorrhage - massive transfusion - hemostasis
 

  • References

  • 1 Kung HC, Hoyert DL, Xu J, Murphy SL. Deaths: final data for 2005. Natl Vital Stat Rep 2008; 56: 1-120
    PubMedGoogle Scholar
  • 2 Kwee A, Bots ML, Visser GH, Bruinse HW. Emergency peripartum hysterectomy: a prospective study in The Netherlands. Eur J Obstet Gynecol Reprod Biol 2006; 124: 187-192
    CrossrefPubMedGoogle Scholar
  • 3 Holcomb JB, Wade CE, Michalek JE , et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008; 248: 447-458
    PubMedGoogle Scholar
  • 4 Pacheco LD, Saade GR, Gei AF, Hankins GD. Cutting-edge advances in the medical management of obstetrical hemorrhage. Am J Obstet Gynecol 2011; 205: 526-532
    CrossrefPubMedGoogle Scholar
  • 5 Rajasekhar A, Gowing R, Zarychanski R , et al. Survival of trauma patients after massive red blood cell transfusion using a high or low red blood cell to plasma transfusion ratio. Crit Care Med 2011; 39: 1507-1513
    CrossrefPubMedGoogle Scholar
  • 6 Nascimento B, Callum J, Rubenfeld G, Neto JB, Lin Y, Rizoli S. Clinical review: Fresh frozen plasma in massive bleedings—more questions than answers. Crit Care 2010; 14: 202
    CrossrefPubMedGoogle Scholar
  • 7 Ickx BE. Fluid and blood transfusion management in obstetrics. Eur J Anaesthesiol 2010; 27: 1031-1035
    CrossrefPubMedGoogle Scholar
  • 8 Glassford NJ, Bellomo R. Acute kidney injury: how can we facilitate recovery?. Curr Opin Crit Care 2011; 17: 562-568
    CrossrefPubMedGoogle Scholar
  • 9 Herrler T, Tischer A, Meyer A , et al. The intrinsic renal compartment syndrome: new perspectives in kidney transplantation. Transplantation 2010; 89: 40-46
    CrossrefPubMedGoogle Scholar
  • 10 Yunos NM, Bellomo R, Story D, Kellum J. Bench-to-bedside review: chloride in critical illness. Crit Care 2010; 14: 226
    Google Scholar
  • 11 Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 2007; 13: 680-685
    CrossrefPubMedGoogle Scholar
  • 12 Roberts I, Shakur H, Ker K, Coats T. CRASH-2 Trial collaborators. Antifibrinolytic drugs for acute traumatic injury. (review) Cochrane Database Syst Rev 2011; (1) CD004896
    PubMedGoogle Scholar
  • 13 Cotton BA, Gunter OL, Isbell J , et al. Damage control hematology: the impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma 2008; 64: 1177-1182 ; discussion 1182–1183
    CrossrefPubMedGoogle Scholar
  • 14 Wafaisade A, Maegele M, Lefering R , et al; Trauma Registry of DGU. High plasma to red blood cell ratios are associated with lower mortality rates in patients receiving multiple transfusion (4 ≤ red blood cell units <10) during acute trauma resuscitation. J Trauma 2011; 70: 81-88 ; discussion 88–89
    CrossrefPubMedGoogle Scholar
  • 15 Snyder CW, Weinberg JA, McGwin Jr G , et al. The relationship of blood product ratio to mortality: survival benefit or survival bias?. J Trauma 2009; 66: 358-362 ; discussion 362–364
    CrossrefPubMedGoogle Scholar
  • 16 Scalea TM, Bochicchio KM, Lumpkins K , et al. Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surg 2008; 248: 578-584
    PubMedGoogle Scholar
  • 17 Stanworth SJ, Birchall J, Doree CJ, Hyde C. Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia. Cochrane Database Syst Rev 2007; (2) CD005011
    PubMedGoogle Scholar
  • 18 Spahn DR, Cerny V, Coats TJ , et al; Task Force for Advanced Bleeding Care in Trauma. Management of bleeding following major trauma: a European guideline. Crit Care 2007; 11: R17
    CrossrefPubMedGoogle Scholar
  • 19 Johansson PI, Ostrowski SR, Secher NH. Management of major blood loss: an update. Acta Anaesthesiol Scand 2010; 54: 1039-1049
    CrossrefPubMedGoogle Scholar
  • 20 Bell SF, Rayment R, Collins PW, Collis RE. The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage. Int J Obstet Anesth 2010; 19: 218-223
    CrossrefPubMedGoogle Scholar
  • 21 Gonzalez EA, Moore FA, Holcomb JB , et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma 2007; 62: 112-119
    CrossrefPubMedGoogle Scholar
  • 22 Gilliss BM, Looney MR, Gropper MA. Reducing noninfectious risks of blood transfusion. Anesthesiology 2011; 115: 635-649
    CrossrefPubMedGoogle Scholar
  • 23 Levi M, Levy JH, Andersen HF, Truloff D. Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 2010; 363: 1791-1800
    CrossrefPubMedGoogle Scholar