Natural products from plants and their synthetic analogs against pests

KM Meepagala; U Bernier; C Burandt; SO Duke

doi:10.1055/s-0032-1321361

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Planta Med 2012; 78 - PL27
DOI: 10.1055/s-0032-1321361

Natural products from plants and their synthetic analogs against pests

KM Meepagala ¹, U Bernier ², C Burandt ³, SO Duke ¹

¹USDA-ARS, NPURU, P.O. Box 8048, University, MS 38677
²USDA-ARS-CMAVE, Mosquito and Fly Research Unit, 1600–1700 SW 23RD Drive, Gainesville, FL, 32608
³NCNPR University of Mississippi, University, 38677

Congress Abstract

As USDA and DoD joint efforts to search for effective, environmentally friendly vector borne disease transmission controlling agents, natural products isolated from plant extracts belonging to various families were evaluated for activity against mosquitoes. The compounds were tested against Ae. egypti for activity as larvicides and repellents. The most popular mosquito repellent has recently been found to have neurotoxic effects and thus new compounds with varying modes of action are needed for public health and military applications. These active compounds were isolated from plants in Asteraceae, and Rutaceae plant families. A moderately active amide isolated from a member of the Rutaceae family has been modified to obtain highly potent repellents with three times longer duration of protection (>6 days) than DEET when tested on cloth patch assay against Ae. egypti female mosquitoes. Isolation, synthesis of analogs and biological activities of these compounds will be discussed.