Planta Med 2012; 78 - PK16
DOI: 10.1055/s-0032-1321332

Natural product-like skeletons from curcuminoids under oxidative dearomatization conditions

Z Cheikh-Ali 1, L Evanno 1, L Ferrié 1, P Champy Erwan Poupon 1
  • 1Université Paris-Sud, Laboratoire de Pharmacognosie associé au CNRS, UMR 8076 BioCIS, LabEx LERMIT, 5, rue Jean-Baptiste Clément, 92296 Châtenay-Malabry Cedex, France

Curcumin, a natural diarylheptanoid polyphenol found for example in turmeric (Curcuma longa, Zingiberaceae), has recently gained a particular interest for an impressive number of biological activities and its putative therapeutic or chemopreventive effects on various health disorders [1]. Under oxidative dearomatization conditions, a complete remodeling of several natural analogs of curcumin is observed and leads to interesting new skeletons that will be presented.

[1] S. C. Gupta, S. Prasad, J. H. Kim, S. Patchva, L. J. Webb, I. K. Priyadarsini, B. B. Aggarwal, Nat. Prod. Rep. 2011, 28, 1937–1955.