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Planta Med 2012; 78 - PK16
DOI: 10.1055/s-0032-1321332
DOI: 10.1055/s-0032-1321332
Natural product-like skeletons from curcuminoids under oxidative dearomatization conditions
Curcumin, a natural diarylheptanoid polyphenol found for example in turmeric (Curcuma longa, Zingiberaceae), has recently gained a particular interest for an impressive number of biological activities and its putative therapeutic or chemopreventive effects on various health disorders [1]. Under oxidative dearomatization conditions, a complete remodeling of several natural analogs of curcumin is observed and leads to interesting new skeletons that will be presented.
[1] S. C. Gupta, S. Prasad, J. H. Kim, S. Patchva, L. J. Webb, I. K. Priyadarsini, B. B. Aggarwal, Nat. Prod. Rep. 2011, 28, 1937–1955.