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Planta Med 2012; 78 - PK4
DOI: 10.1055/s-0032-1321320
DOI: 10.1055/s-0032-1321320
Asymmetric synthesis of Pterolinus D derivatives
Pterolinus D was an active component of anti-inflammatory activity and cytotoxicity from Pterocarpus santalinus. Herein, an asymmetric synthesis of pterolinus D derivatives (7a-b, 7'a-7'b) was processed by Evans chiral auxiliary methodology to introduce a methyl stereogenic center, followed by Friedel-Crafts reaction and LiAlH4 reduction to give an hydroxyl stereogenic center as a Cram isomer. The structures are confirmed by NMR, MS and CD-ORD spectroscopy methods.