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Planta Med 2012; 78 - PK2
DOI: 10.1055/s-0032-1321318
DOI: 10.1055/s-0032-1321318
Synthesis of γ-benzopyranones using sonogashira coupling and 18-crown-6 ether mediated cyclization
An efficient method for the synthesis of γ-benzopyranones and flavones utilizing mild Sonogashira coupling and 18-crown-6 ether mediated 6-endo cyclization of o-alkynoylphenol acetates has been developed. By using this strategy, γ-benzopyranones and flavones bearing electron-donating groups, halogens and simple alkyl substituents were synthesized with satisfactory yields.