Planta Med 2012; 78 - PJ131
DOI: 10.1055/s-0032-1321291

Batatins VII-X, glycolipid ester-type dimers from sweet potato (Ipomoea batatas)

D Rosas-Ramírez 1, R Pereda-Miranda 1
  • 1Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, 04510 Mexico

Batatins VII-X (1-4) were purified from the resin glycoside contents of the tuberous roots of three varieties of sweet potato, using different HPLC techniques. Their structures were characterized by means of several high-resolution NMR and MS techniques and the main structural differences were found in the site of lactonization to form the macrocyclic structure, the type of acylating residues, and the position of esterification to establish the ester-type dimer. Different types of acid residues esterified each unit: (2S)-methylbutanoic, cinnamic, decanoic and dodecanoic acids. Morning-glory resin glycosides have shown to modulate the multidrug resistance developed to therapeutic agents by microorganisms and tumor cells. Dimeric structures in the convolvulaceae family have been described previously, being of the specie of Ipomoea batatas which have been isolated and characterized more diversity, batatins I-X. Financial Support: DGAPA, UNAM (IN217310) and CONACyT (101380-Q).

3. R1 and R2=decanoic

4. R1 and R2=dodecanoic