Isolation, structure elucidation and antiplasmodial activity of novel bisindole alkaloids from Gonioma malagasy

MA Beniddir; MT Martin; ME Tran Huu Dau; P Grellier; P Rasoanaivo; F Guéritte; M Litaudon

doi:10.1055/s-0032-1321276

Planta Medica, Inhaltsverzeichnis

Isolation, structure elucidation and antiplasmodial activity of novel bisindole alkaloids from Gonioma malagasy

MA Beniddir ¹, MT Martin ¹, ME Tran Huu Dau ¹, P Grellier ², P Rasoanaivo ³, F Guéritte ¹, M Litaudon ¹

¹Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Labex LERMIT, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
²Muséum National d'Histoire Naturelle, UMR 7245 CNRS, Team APE, CP 52, 61, Rue Buffon, 75231 Paris Cedex 05, France
³Institut Malgache de Recherches Appliquées, B. P. 3833, 102 Antananarivo, Madagascar

Abstract

In the frame of the search for antiplasmodial compounds from the Madagascarian biodiversity, we chemically and biologically investigated the endemic species G.malagasy Boiteau (Apocynaceae). Five novel bisindole alkaloids possessing an unprecedented linkage between the two indole moieties have been isolated and characterized. The planar structure of the main compound (fig.1) was elucidated using usual spectroscopic methods, while its absolute configuration was deduced following the comparison of experimental and theoretically calculated ECD spectra, and through biogenetic consideration. We will report in this communication, their isolation, structure elucidation and antiplasmodial activities.