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Planta Med 2012; 78 - PJ116
DOI: 10.1055/s-0032-1321276
DOI: 10.1055/s-0032-1321276
Isolation, structure elucidation and antiplasmodial activity of novel bisindole alkaloids from Gonioma malagasy
In the frame of the search for antiplasmodial compounds from the Madagascarian biodiversity, we chemically and biologically investigated the endemic species G.malagasy Boiteau (Apocynaceae). Five novel bisindole alkaloids possessing an unprecedented linkage between the two indole moieties have been isolated and characterized. The planar structure of the main compound (fig.1) was elucidated using usual spectroscopic methods, while its absolute configuration was deduced following the comparison of experimental and theoretically calculated ECD spectra, and through biogenetic consideration. We will report in this communication, their isolation, structure elucidation and antiplasmodial activities.