Spectroscopic networking based dereplication applied to a strain of Moorea producens affords a fuller picture of its metabolome

PD Boudreau; PC Dorrestein; WH Gerwick

doi:10.1055/s-0032-1321253

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Planta Med 2012; 78 - PJ93
DOI: 10.1055/s-0032-1321253

Spectroscopic networking based dereplication applied to a strain of Moorea producens affords a fuller picture of its metabolome

PD Boudreau ¹, PC Dorrestein ²^,³, WH Gerwick ¹^,³

¹Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States
²Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California 92093, United States
³Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States

Congress Abstract

Moorea producens JHB is a well-studied strain of cyanobacteria from which our laboratory has isolated hectochlorin (1), and the jamacamides (2–4). Using spectroscopic networking an extract of this cyanobacterium was profiled based on the MS² fragmentation patterns of the metabolome. While the known compounds 1–4 were readily observed, a suite of unreported compounds related to 1 were also observed, along with another independent series of compounds related to 2–4. These minor metabolites and the techniques used to discover them will be presented.