Planta Med 2012; 78 - PJ89
DOI: 10.1055/s-0032-1321249

Fast and efficient process for recovery of naturally abundant chiral synthon: Iridoids from Lonicera tatarica

H Lemoine 1, R Grougnet 1, B Deguin 1
  • 1Laboratoire de Pharmacognosie de l'Université Paris Descartes, Sorbonne Paris Cité, UMR/CNRS 8638, Faculté des Sciences Pharmaceutiques et Biologiques, 4, Avenue de l'Observatoire, 75006, Paris

Dedicated to the memory of Pr François Tillequin

The genus Lonicera (Caprifoliaceae) is a rich source of iridoids, such as secologanin 1 and sweroside 2. These highly functionalized monoterpenes represent a new class of chiral synthons for semisynthesis. Therefore we developed a new and fast process to recover these products from the leaves of Lonicera tatarica by Centrifugal Partition Chromatography. Major compounds of the stems where also separated and identified as loganingenin 3, loganin 4, and periclymenoside 5. In the context of green chemistry, this easy up-scalable process represent significant improvement as it is silica free and it replaces chlorinated solvents with water and small quantities of organic solvents.