Gas chromatography of epoxide compounds from microencapsulated Varronia verbenacea essential oil after storage

RAF Rodrigues; KB de F Paganotti; MA Foglio; VLG Rehder; GM Figueira; IMO Sousa; FAA de Oliveira; MVN Rodrigues

doi:10.1055/s-0032-1321207

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Planta Med 2012; 78 - PJ47
DOI: 10.1055/s-0032-1321207

Gas chromatography of epoxide compounds from microencapsulated Varronia verbenacea essential oil after storage

RAF Rodrigues ¹, KB de F Paganotti ¹, MA Foglio ¹, VLG Rehder ¹, GM Figueira ¹, IMO Sousa ¹, FAA de Oliveira ¹, MVN Rodrigues ¹

¹UNICAMP-University of Campinas, PO Box 6171, Zip Code 13083–970, Campinas, SP, Brazil

Kongressbeitrag

Varronia verbenacea (DC.) Borhidi (popular erva-baleeira) has anti-inflammatory activity attributed to α-humulene. The oil's activity can be lost during storage. Polimeric microparticles is an option to increase stability for pharmaceutical preparations. The profile of epoxides generated on storage was simulated by epoxidation reaction of the essential oil with meta-chloroperbenzoic acid. Erva-baleeira's essential oil was obtained by steam distillation and the respective microparticles by spray-drying technique with cashew gum as wall material. The epoxides were identification by GC/MS analysis. The fragmentation of some compounds showed mono and di-epoxides as compared with reported data (mono 1–3 and 4–6 di-epoxides) (Lam & Deinzer 1987J Agric Food Chem.).