Planta Med 2012; 78 - PJ8
DOI: 10.1055/s-0032-1321168

Chromatogaphic determination of molar absorptivity of natural prenyloxycinnamic acids in standardless analysis

G Carlucci 1, F Epifano 1, S Genovese 1, M Locatelli 1
  • 1Dipartimento di Scienze del Farmaco, Università degli Studi ''G. d'Annunzio'' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti (CH), Italy

In recent years naturally occurring prenyloxycinnamic acids were shown to exert remarkable anti-cancer and anti-inflammatory effects. 4'-Geranyloxyferulic acid was found efficient as an active chemopreventive agent, and its structural analogue boropinic acid was shown to exert inhibitory effects against the growth of Helicobacter pylori. We report herein the comparison between traditional and HPLC-DAD methods for the molar absorptivity coefficient determination of 4-geranyloxyferulic acid (ε310=12,950 and ε288=11,910 Lmol-1cm-1) and boropinic acid (ε310=13,510 and ε288=12,350 Lmol-1cm-1). The data reported, as a continuation of previously reported work [1], will be useful for future studies aimed to better define the pharmacological profile, the mechanism of action of the title compounds, and to evaluate other natural products where standard powders are not available.

References

[1] Genovese S. et al., Journal of Pharmaceutical and Biomedical Analysis (2010) 53:212–214.