Planta Med 2012; 78 - PI460
DOI: 10.1055/s-0032-1321147

Schistosomicidal potential of endophytic fungi associated with Vochysia divergens Pohl

RCN Pedroso 1, LP Pimenta 1, WC Lima 2, MA Soares 3, LG Magalhães 1, AEM Crotti 1, MLA Silva 1, WR Cunha 1, PM Pauletti 1, AH Januário 1
  • 1Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, CP 82, 14404–600 Franca-SP, Brazil
  • 2Instituto de Ciências Exatas e da Terra
  • 3Instituto de Biociências, Universidade Federal de Mato Grosso, Av. Fernando Corrêa da Costa, 2367, 78060–900, Cuiabá-MT, Brazil

Schistosomiasis, caused by trematode flatworms of the genus Schistosoma, is one of the most significant, neglected tropical diseases in the world. Vochysia divergens (Vochysiaceae), popularly known as “Cambará”, is a typical species of the Mato Grosso Pantanal. In this work, ethyl acetate extracts of endophytic fungi 43W and 53W strains associated with V. divergens roots were chemically investigated and also evaluated in vitro against Schistosoma mansoni adult worms for viability and motor activity. The compound 2-hydroxy-10-(3,4-dihydroxyphenyl) decanoic acid (1) was identified as the major constituent from the strain 53W. The structural elucidation, established by NMR spectroscopic and mass spectrometric analysis of 1 as well as the biological results will be presented.