Anti-phytopathogen potential of diterpenes against Colletotrichum gloeosporioides and Fusarium verticilloides

AT Frias; GH Braun; HP Ramos; TS Porto; SR Ambrósio; S Said

doi:10.1055/s-0032-1321108

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Planta Med 2012; 78 - PI421
DOI: 10.1055/s-0032-1321108

Anti-phytopathogen potential of diterpenes against Colletotrichum gloeosporioides and Fusarium verticilloides

AT Frias ¹, GH Braun ¹, HP Ramos ¹, TS Porto ², SR Ambrósio ², S Said ¹

¹Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Av. do Café s/n, 14040–903, Ribeirão Preto, SP, Brazil
²Universidade de Franca, Av. Dr. Armando Sales de Oliveira, 201, Pq. Universitário, 14 404–600, Franca, SP, Brazil

Congress Abstract

Many diterpenes from plants and fungi are being reported with significant antimicrobial activity. Herein the anti-phytopathogen activity of twenty four diterpenes obtained from several botanical sources and semi-synthetic methodologies were tested against the fungi Colletotrichum gloeosporioides, one of the responsible for anthracnose in many fruits and Fusarium verticilloides which infects mainly maize. The minimum inhibitory concentration (MIC) and the half maximal inhibitory concentration (IC₅₀) of these metabolites were determined. The best activity analyzed by MIC and IC₅₀ against C. gloeosporioides and F. verticilloides were detected with ent-copalic acid, (-)-hydroxycopalic acid methyl ester, ent-agathic acid methyl ester, sodium salt of ent-pimara-8(14),15-dien-19-oic acid, dehydroabietic acid and esclareol. In conclusion, ours results pointed out diterpenes as an important class of natural products in the search for novel anti-phytopathogenic agents.