Activities of xanthones against intramacrophage amastigotes of Leishmania (Leishmania) Amazonensis

LS Espindola; EM Silva; RM Araújo; R Braz-Filho

doi:10.1055/s-0032-1321091

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Planta Med 2012; 78 - PI404
DOI: 10.1055/s-0032-1321091

Activities of xanthones against intramacrophage amastigotes of Leishmania (Leishmania) Amazonensis

LS Espindola ¹, EM Silva ¹, RM Araújo ², R Braz-Filho ³

¹Laboratório de Farmacognosia, Universidade de Brasília, Brasília, Brazil
²Departamento de Química, Universidade Federal do Rio Grande do Norte, Natal, Brazil
³Departamento de Química, Universidade Federal Rural do Rio de Janeiro, Seropédica, Brazil

Congress Abstract

The current treatment of cutaneous leishmaniasis is hampered by factors such as toxicological effects, low adherence due long term administration and drug resistance (The Lancet, 2010, 376, 1363). Therefore, we have isolated a previously unreported xanthone (1), 6,9-dihydroxy-3,3-dimethyl-5-(3-methylbut-2-enyl)pyrano[2,3-c]xanthen-7(3H)-one, from ethyl acetate extract of Clusia pernambucensis G. Mariz (Clusiaceae) stem bark. In addition, a derivative of the same compound (1a) was obtained to compare and enhance the activity against the intramacrophage amastigote forms of Leishmania (Leishmania) amazonensis. The IC₅₀ observed for both compounds were 25.2 and 22.5µg/mL, respectively. In murine macrophages, the CC50 values were 17.22µg/mL for 1 and 32.56µg/mL for 1a.