Phytochemical analysis of alkaloids from the icelandic club moss Diphasiastrum alpinum (L.) Holub

ES Halldorsdottir; RH Palmadottir; NT Nyberg; ES Olafsdottir

doi:10.1055/s-0032-1321089

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Planta Med 2012; 78 - PI402
DOI: 10.1055/s-0032-1321089

Phytochemical analysis of alkaloids from the icelandic club moss Diphasiastrum alpinum (L.) Holub

ES Halldorsdottir ¹, RH Palmadottir ¹, NT Nyberg ², ES Olafsdottir ¹

¹Faculty of Pharmaceutical Sciences, School of Health Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland
²Faculty of Health and Medicinal Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark

Congress Abstract

A new alkaloid, O-acetylepiclavolonine (1), has been isolated from the Icelandic club moss Diphasiastrum alpinum and the structure has been determined using a combination of mass spectrometry, NMR and optical rotation. The previously described alkaloids O-acetylfawcettiine (2), O-acetyllofoline (3), lycodoline (4) and anhydrolycodoline (5) were found in D. alpinum for the first time together with the expected lycopodine and clavolonine. The isolated alkaloids (1-5) did not show significant inhibition of acetylcholinesterase in vitro. Two alkaloids found in European alpine club moss, lycoclavine and des-N-methyl-α-obscurine, were not detected in the Icelandic plant material indicating an influence of different environmental conditions on the alkaloid profiles.