Chemical screening of mimosaceae from Senegal for the identification of avicins analogues

OP Noté; C Antheaume; FB Sar; D Goffner; M Sarr; A Lobstein

doi:10.1055/s-0032-1321085

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Planta Med 2012; 78 - PI398
DOI: 10.1055/s-0032-1321085

Chemical screening of mimosaceae from Senegal for the identification of avicins analogues

OP Noté ¹^,², C Antheaume ³, FB Sar ⁴, D Goffner ⁴, M Sarr ⁴, A Lobstein ¹

¹Pharmacognosy and Bioactive Natural Products, UMR 7200, University of Strasbourg (France)
²Department of Organic Chemistry, University of Yaoundé I (Cameroun)
³SCA, UMR 7200, University of Strasbourg (France)
⁴UMI 3189, FMPO, University Anta Diop of Dakar (Sénégal)

Congress Abstract

Avicins are complex electrophile triterpene glycosides with high anticancer potential, and until now only isolated from an Australian desert tree, Acacia victoriae. In order to discover new avicins analogues, nine Mimosaceae (Leguminosea) from three different genera (Albizia, Acacia and Dischrostachys) collected in Senegal were screened for their saponin content. Chemical analysis of the saponin-enriched fractions using HPTLC-MS, LC-UV, and NMR (1D and 2D) experiments, pointed out the presence of avicins analogues exclusively in Albizia species. These findings confirm that Albizia can be considered as the most reliable genus for the isolation and identification of new acacic acid derivatives from African Mimosaceae.