Planta Med 2012; 78 - PI374
DOI: 10.1055/s-0032-1321061

MAO-A inhibitory activities of some benzophenones from Gentiana Spec

F Yalçın 1, D Kaya 1, A Jäger 2, T Ersöz 1
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Sıhhiye, Ankara, Turkey
  • 2Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark

Inhibition of MAO-A predominantly affects neurotransmitters considered to be important in depression and anxiety disorders. Therefore, MAO inhibitors are expected to be useful in the therapy of psychosis, depression, schizophrenia, and so on (1). To date, MAO inhibitors such as coumarins, xanthones, flavonoids, piperine, and isoquinoline alkaloids have been isolated from natural sources or synthesized for the development of medicine (1–4). In this study MAO-A inhibition of benzophenone glucosides 1, 2 and 3 isolated from G. verna L. subsp. pontica (Soltok.) Hayek. was evaluated. Compounds 1-3 showed significant inhibition on MAO-A with IC50-values 1.2–34µM.

1

R1=H,

R2=CH3

2

R1=OH,

R2=H

3

R1=H,

R2=H

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