Anti-ages activity screening of molecules isolated from Tanzanian clusiaceous species

Advanced glycation end-products (AGEs) are involved in the progression of numerous pathologies such as diabetes or atherosclerosis. With the objective of finding molecules with inhibitory effects on AGEs formation, we have conducted a phytochemical investigation on three Tanzanian Clusiaceous species: Garcinia semseii, Garcinia volkensii and Allanblackia uluguruensis. Several polyphenolic compounds exhibiting phloroglucinol moieties [e.g. polyprenylated benzophenones, such as guttiferone F (1) or biflavonoïds, such as morelloflavone (2)] were identified and their anti-AGEs activities were evaluated using a recently developed automated assay.