Planta Med 2012; 78 - PI367
DOI: 10.1055/s-0032-1321054

Estrogenic and anti-estrogenic compounds from Thai medicinal plant, Cleome gynandra

K Umehara 1, B Wungsintaweekul 2, T Miyase 1, H Noguchi 1
  • 1School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422–8526, Japan
  • 2Faculty of Pharmaceutical Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand

An edible Thai plant, Cleome gynandra L. (Capparaceae) was investigated for its estrogenic and antiestrogenic compounds as it has been traditionally used for improvement of menstrual dysfunctions in Thailand. The dried aerial parts of C. gynandra (1.7kg) were extracted with methanol. The extract (150g) was applied for bioassay-guided isolation by using estrogen-responsive cancer cells MCF-7 and T47D. From the extract, novel dammarane triterpenes (1–5) were isolated with some known compounds. Their structural characterization will be presented with their estrogenic and anti-estrogenic activities.