Planta Med 2012; 78 - PI356
DOI: 10.1055/s-0032-1321043

The chemical profile on pyrrolizidine alkaloids of selected endemic Greek boraginaceae plants of Onosma genus

H Damianakos 1, G Sotiroudis 2, I Chinou 1
  • 1Dept. of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Zografou, 15771, Athens, Greece
  • 2Institute of Biological Research-Biotechnology, National Research Institute, 11635, Athens, Greece

In the framework of our studies on Greek Boraginaceae plants, we report here the phytochemical analyses on the extracts of three endemic plants of Onosma genus (Onosma leptantha Heldr., O. erecta Sibth.& Sm., and O. kaheirei Teppner). Chemical isolations were focused on pyrrolizidine alkaloids (PAs) content, as their corresponding N-oxides (PANOs) or as free bases of the acyclic mono- and di-esteric type. The PANOs were structurally determined through modern spectral data (NMR, MS) and five new compounds were identified while the free bases PAs were detected by GC-MS on the basis of their RI values, molecular ion peaks and MS fragmentation pattern.