A new diterpenoid from Salvia adenophora Fernald (Lamiaceae)

A Bisio; G Damonte; E Giacomelli; G Mele; A Profumo; G Romussi; N De Tommasi

doi:10.1055/s-0032-1321042

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Planta Med 2012; 78 - PI355
DOI: 10.1055/s-0032-1321042

A new diterpenoid from Salvia adenophora Fernald (Lamiaceae)

A Bisio ¹, G Damonte ², E Giacomelli ¹, G Mele ¹, A Profumo ³, G Romussi ¹, N De Tommasi ⁴

¹Department of Pharmacy, University of Genoa, Via Brigata Salerno, 16147 Genoa, Italy
²Center of Excellence for Biomedical Research, Viale Benedetto XV 7, 16132, Genoa, Italy
³S.C. Integrated Molecular Pathology- IRCCS AOU San Martino – IST- 16132 Genoa
⁴Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Salerno, Italy

Congress Abstract

The surface exudate obtained by rinsing the aerial parts of Salvia adenophora with CH₂Cl₂ was subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS followed by semi-preparative RP-HPLC. Some known diterpenes have been isolated together with a new clerodane diterpenoid 1, identified by IR, NMR, including TOCSY, COSY, HSQC, HMBC and ROESY experiments, ESI-TRAP-MS and HR-MS analysis.