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DOI: 10.1055/s-0032-1321033
Effect of polyphenols from Aronia melanocarpa on the total oxidative and antioxidative bone status of cadmium-exposed rats
Bone damage belongs to the main health effects of chronic exposure to cadmium and oxidative stress is involved in its pathogenesis. It was investigated whether polyphenolic compounds, possessing antioxidative properties, may improve the bone oxidative/antioxidative status under exposure to cadmium. Total oxidative (TOS) and antioxidative (TAS) status, and the level of oxidative stress (OSI=TOS/TAS) of the bone tissue at the distal femur (trabecular bone region) of the female Wistar rats administered as the only drinking fluid 0.1% water extract of polyphenolic compounds from the berries of Aronia melanocarpa or/and cadmium (1 and 5mg/kg diet) for 3 and 10 months were estimated. The exposure to cadmium alone, dose and duration dependently, decreased the bone tissue antioxidative capacity and/or increased its oxidative status leading to the development of oxidative stress. The administration of polyphenolic compounds during cadmium exposure improved the oxidative/antioxidative balance of the bone tissue preventing oxidative stress. It can be concluded that consumption of polyphenol-rich products such as berries of Aronia melanocarpa under chronic exposure to cadmium may have beneficial impact on the skeleton via improving the oxidative/antioxidative balance of the bone tissue.
This study was financially supported by the Grant (No. N N405 051140) from the National Science Centre (Poland).