Abietane diterpenoids from some salvia species: Chemical transformations and antiproliferative activity

In this research the major secondary metabolites isolated from these species and their biological studies against five human cancer cell lines are described. A cold acetone extract of the aerial parts of S. pachyphylla was chromatographed on silica gel to give nine known natural products and the new diterpene identified on the basis of spectroscopic data analysis. From the aerial parts of S. clevelandii, seven known diterpenes were obtained and identified by comparison with the spectroscopic data found in the bibliography. The antiproliferative activity of the isolated metabolites was evaluated in vitro against A2780 ovarian cancer, SW1573 non-small-cell lung cancer, WiDr colon cancer, T-47D breast cancer, and HBL-100 breast cancer cells. Finally a series of β-amino alcohol analogs of sugiol were synthesized in a straightforward manner. The in vitro cytotoxic activities were examined, and the most potent analogs induced considerably growth inhibition in the range of 1.5–6.7µM.