Isolation of cytotoxic constituents from Carex vulpinoidea seeds

D Niesen; A González-Sarrías; H Ma; T Yuan; GE Henry; NP Seeram

doi:10.1055/s-0032-1320993

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Planta Med 2012; 78 - PI306
DOI: 10.1055/s-0032-1320993

Isolation of cytotoxic constituents from Carex vulpinoidea seeds

D Niesen ¹, A González-Sarrías ¹, H Ma ¹, T Yuan ¹, GE Henry ², NP Seeram ¹

¹Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, United States
²Department of Chemistry, Susquehanna University, Selinsgrove, PA 17870, United States

Congress Abstract

Recent studies from our group have identified bioactive stilbenoids, including resveratrol oligomers, from previously uninvestigated Carex species collected in Pennsylvania, United States. Here, Carex vulpinoidea seeds were evaluated using cytotoxicity-assay guided isolation against human colon cancer (HCT-116; Caco-2) cells. Hopeaphenol (1) (IC₅₀=2–5µM), a resveratrol tetramer, was identified as a major bioactive compound along with other polyphenols including luteolin (2), 3,5,5',7' tetrahydroxyflavanone (3) and methylated naringenin (4).