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Planta Med 2012; 78 - PI306
DOI: 10.1055/s-0032-1320993
DOI: 10.1055/s-0032-1320993
Isolation of cytotoxic constituents from Carex vulpinoidea seeds
Recent studies from our group have identified bioactive stilbenoids, including resveratrol oligomers, from previously uninvestigated Carex species collected in Pennsylvania, United States. Here, Carex vulpinoidea seeds were evaluated using cytotoxicity-assay guided isolation against human colon cancer (HCT-116; Caco-2) cells. Hopeaphenol (1) (IC50=2–5µM), a resveratrol tetramer, was identified as a major bioactive compound along with other polyphenols including luteolin (2), 3,5,5',7' tetrahydroxyflavanone (3) and methylated naringenin (4).