Planta Med 2012; 78 - PI291
DOI: 10.1055/s-0032-1320978

Cornoside A, a new monoterpenoid glucosid with an unusual skeleton from Cornus controvers

Y He 1, 2, J Peng 3, G Ma 3, LM West 2, MT Hamann 3
  • 1Department of Applied Chemsitry, Xi'an University of Technology, Xi'an 710054, China
  • 2Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431
  • 3Department of Pharmacognosy, School of Pharmacy, University of Mississippi, Oxford, MS 38677
  • 4Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229

A novel monoterpenoid glucoside with an unprecedented 2-oxabicyclo-[2.2.1]-heptan-3-one rearranged ring system was isolated from Cornus controversa and named cornoside A (1). The structure and relative stereochemistry was elucidated on the basis of extensive spectroscopic analysis. Cornoside A represents an unprecedented rearrangement iridoid. In addition, the novel compound exhibited potent LXR agonistic activity and moderate PPARγ agonistic activity.