Planta Med 2012; 78 - PI287
DOI: 10.1055/s-0032-1320974

Indole alkaloids from Duroia macrophylla (Rubiaceae)

CV Nunez 1, V Roumy 2, DWO Mesquita 1, 3, ASS Mesquita 1, 3, S Sahpaz 2, F Bailleul 2, T Hennebelle 2
  • 1Laboratório de Bioprospecção, Coordenação de Pesquisas em Produtos Naturais, Instituto Nacional de Pesquisas da Amazônia, Aleixo, Manaus, Amazonas, 69060–001, Brazil
  • 2Laboratoire de Pharmacognosie, EA 4481, Université de Lille, 59006 Lille, France
  • 3Departamento de Engenharia de Produção Agroindustrial, Campus de Cacoal, Universidade Federal de Rondônia, RO, Brazil

Duroia macrophylla Huber (Rubiaceae) is a tropical tree, known as “puruí”, which occurs in the Amazon region. The study of the methnolic extract led to the isolation of the indolic alkaloids 9-methoxyajmalicine and 10-methoxyajmalicine (cabucine) which were identified by NMR and MS data analyses. The methanolic extract was toxic against Artemia salina (IC50=40µg/mL).