Triterpene glycosides from Planchonella obovata leaves

HY Chen; JH Guh; SS Lee

doi:10.1055/s-0032-1320972

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Planta Med 2012; 78 - PI285
DOI: 10.1055/s-0032-1320972

Triterpene glycosides from Planchonella obovata leaves

HY Chen ¹, JH Guh ¹, SS Lee ¹

¹School of Pharmacy, College of Medicine, National Taiwan University, 1, Jen-Ai Rd., Sec. 1, Taipei 10051, Taiwan, Republic of China

Congress Abstract

Continual chemical investigation of the BuOH-soluble fraction of the leaves of Planchonella obovata (R. Br.) Pierre (Sapotaceae) led to the isolation of eight triterpene glycosides as well as nine flavonoids. Their structures were elucidated based on spectroscopic analyses, in particular using 1D TOCSY to identify the various sugar moieties. The configuration of each monosaccharide in the glycon part was determined by GC method. Among these, compounds 3-5 are new natural products. 3'''-O-β-D-Apiofuranosylarganin F (4) and Mi-saponin A (6) showed moderate cytotoxic activity against HL-60 leukemia cell line with the IC₅₀ values of 16.88 and 15.50 µM, respectively.