Three new cyclic diarylheptanoids from Santalum album

Santalum album L. is a tropical evergreen tree which is one of the most widespread members of the Santalaceae family in India, Malaysia, South China, and Australia. It is commonly known as sandalwood. The essential oil of sandalwood has been used as an aromatherapy as an antidepressant, sedative, antifungal, anti-inflammatory, insecticide, and lung antiseptic. Previous phytochemical studies on this plant have been reported that it contained sesquiterpenoids, phenylpropanoids, diarylheptanoids, and lignans. As part of our continuing search for the discovery of new bioactive constituents from medicinal plant, we investigated an ethylacetate-soluble fraction of the MeOH extract of S. album. Three new cyclic diarylheptanoids along with six known compounds were isolated and identified. Their structures were determined on the basis of results of spectroscopic analysis, including 1D- and 2D-NMR spectroscopic data. Here, we report the isolation and structure elucidation of these three new cyclic diarylheptanoids.