Alkaloids from Choisya ternata and their human antiplatelet activity

One novel alkaloid was isolated from the hexane extract of Choisya ternata Kunth. (Rutaceae) leaves, choisyaternatine (1), together with the known alkaloids tecleamaniensine A (2) and skimmianine (3). From the dichloromethane extract, skimmianine (3) and choisyine (4) were also isolated. Tecleamaniensine A is reported for the first time in this species. The structures of isolated compounds were elucidated by extensive spectroscopic analyses and comparison with previously reported spectroscopic data. The structure of choisyaternatine was further confirmed based on X-ray data analysis. Anti-platelet activity of hexane extract, choisyaternatine and skimmianine was also evaluated.