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Planta Med 2012; 78 - PI267
DOI: 10.1055/s-0032-1320954
DOI: 10.1055/s-0032-1320954
Phytochemical and biological studies of two synonymy species of Solanum: S. incanum and S. heteracanthum
A new spirostanol saponin (1), with four known saponins, dioscin (2), protodioscin (3), methylprotodioscin (4), indioside D (5) and one known glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. 1 was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-D-xylopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)-[O-α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including 1H, 13C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. 1, 3, 4 and 5 were evaluated for cytotoxicity and antioxidant activities against six cancer cell lines (HCT 116, HT-29, SW480, DU145, EMT6 and THP-1).