Planta Med 2012; 78 - PI259
DOI: 10.1055/s-0032-1320946

Studies on the constituents of Cudrania tricuspidata

H Sasaki 1, H Sato 1, Y Kashiwada 1, K Kawazoe 2, K Murakami 3, H Shibata 1, HD Sun 4, SL Li 4, Y Takaishi 1
  • 1Graduate School of Pharmaceutical Sciences, University of Tokushima, 1–78 Shomachi, Tokushima 770–8505, Japan
  • 2Department of Clinical Pharmacy, Tokushima University Hospital, 2–50–1 Kuramoto, Tokushima 770–8503, Japan
  • 3Faculty of Pharmaceutical Sciences, Sojo University, 4–22–1 Ikeda, Kumamoto 862–0082, Japan
  • 4Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, China

Cudrania tricuspidata (Moraceae), which is a deciduous tree, widely distributed in Korea and China, has been traditionally used for the treatment of lumbago, hemoptysis, and contusion. As part of our search for bioactive plant metabolites, we have investigated constituents of this plant. The MeOH extract of the roots of C.tricuspidata was partitioned with EtOAc and H2O. The EtOAc-soluble fraction was separated repeatedly by various column chromatografies to yiled a new prenylated xanthone (1) and two new prenylated flavonoids (2 and 7), together with nineteen known compounds. The structures of these compounds were elucidated by extensive spectroscopic analyses including 1D-, 2D-NMR and MS. The antibacterial activities against MRSA as well as the antifungal activities against Aspergillus niger, Candida albicans, Penicillium sp., Rhizopus sp. and Trichophyton sp. of isolated compounds were evaluated. The structure elucidation and the antimicrobial activities of these compounds will be presented.