Planta Med 2012; 78 - PI252
DOI: 10.1055/s-0032-1320939

Antiproliferative compounds from the fabaceae family from the Madagascar dry forest

Y Liu 1, L Harinantenaina 1, PJ Brodie 1, C Slebodnick 1, M Callmander 2, R Randrianaivo 2, E Rakotobe 3, VE Rasamison 3, DGI Kingston 1
  • 1Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, USA
  • 2Missouri Botanical Garden, B.P 3391, Antananarivo 101, Madagascar
  • 3Centre National d'Application des Recherches Pharmaceutiques, B.P. 702, Antananarivo 101, Madagascar

As a part of the International Cooperative Biodiversity Group (ICBG) program, ethanol extracts of the leaves and roots of a plant initially identified as Bussea sakalava (Fabaceae) were selected for evaluation as potential anticancer agents based on activity against the A2780 ovarian cancer cell line. Recent taxonomic studies have indicated that the plant is not B. sakalava. Bioassay-directed fractionation of the leaf extract afforded the new naphthoquinone (1), and a combination separation methods on the root extract afforded the known isoflavonoid bonducellin (2), one new stilbenoid (3) and the four known stilbenoids piceatannol (4), resveratrol (5), rhapontigenin (6), and isorhapontigenin (7). The structure elucidations of all compounds were based on NMR spectra and mass spectroscopic data, and the structure of 1 was confirmed by single crystal X-ray analysis. Compounds 1-5 showed antiproliferative activity against the A2780 human ovarian cancer cell line as shown.