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DOI: 10.1055/s-0032-1320938
Two new triterpenoid saponins from Pittosporum senacia
The Pittosporaceae family is represented by 9 genera, which contains about 250 species, distributed in tropical and subtropical regions. The use for local traditional medicine from species of the Pittosporaceae family has been reported in multiple cases. Some different endemic subspecies of Pittosporum senacia are known to have an indigenous medicinal role in tropical regions for treatment of rheumatism and throat infections. A previous work on the volatile constituents of the leaves of P. senacia var. coursii was reported, whereas triterpene saponins have never been characterized in this species. In this communication we report about the isolation and characterization of two new triterpene saponins, senaciapittosides A (1) and B (2) from Pittosporum senacia. The structures were elucidated by 600MHz NMR analysis including 1D and 2D NMR (1H-, 13C NMR, COSY, TOCSY, ROESY, HSQC and HMBC) spectroscopy and mass spectrometry as 3-O-[β-D-glucopyranosyl-(1→2)]-[α-L-arabinopyranosyl-(1→3)]-[α-L-arabinofuranosyl-(1→4)]-β-D-glucuronopyranosyl-olean-12-en-28-O-β-D-glucopyranosyl ester (1), and 3-O-[β-D-glucopyranosyl-(1→2)]-[α-L-arabinopyranosyl-(1→3)]-[α-L-arabinofuranosyl-(1→4)]-β-D-glucuronopyranosyl-22-O-α-L-arabinopyranosyl-21-acetoxyolean-12-en-3β,15α,16α,21β,22α,28-hexol (2).