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DOI: 10.1055/s-0032-1320929
Growth inhibition of human colon carcinoma cells by diterpenes and tetralones of Zygogynum calothyrsum
Bioassay guided phytochemical investigation of Zygogynum calothyrsum using human colon carcinoma cells COLO205 and KM12 led to the isolation of three new drimane-type diterpenes, 11-hydroxy-11,12-epoxydrimane (1), 5,11-dihydroxy-11,12-epoxydrimane (2) and 11,12-dimethoxy-11,12-epoxydrimane (3), the known 1β-p-coumaroyloxypolygodial (4) together with two new tetralones, 3'-dehydroxyisozygolone (5) and calothyrlone A (9), three known tetralones, isozygolone A (6), zygolone A (7) and 4'-O-methylzygolone A (8) and a known cinnamolide (10). Compounds 1, 7 and 8 demonstrated higher cytotoxicity against COLO205 (GI50=17.8, 16.7 and 11.4 µM, respectively) and KM12 (GI50=13.5, 14.2 and 17.2 µM, respectively) than other compounds.