Planta Med 2012; 78 - PI241
DOI: 10.1055/s-0032-1320928

Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia

L Pan 1, C Terrazas 2, CM Lezama-Davila 2, N Rege 3, JC Gallucci 4, AR Satoskar 2, AD Kinghorn 1
  • 1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy
  • 2Department of Pathology, College of Medicine
  • 4Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA
  • 3Department of Pharmacology, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai 400012, India

Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolide A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs). (Supported by grant RC4 AI092624, from NIAID, NIH)