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Planta Med 2012; 78 - PI241
DOI: 10.1055/s-0032-1320928
DOI: 10.1055/s-0032-1320928
Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia
Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolide A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs). (Supported by grant RC4 AI092624, from NIAID, NIH)