Planta Med 2012; 78 - PI236
DOI: 10.1055/s-0032-1320923

Isolation, characterization and bioactivity of sesquiterpene lactones from Eupatorium lasiophthalmum Griseb

E Maldonado 1, 3, D Svensson 1, S Oredsson 2, O Sterner 1
  • 1Centre of Analysis and Synthesis, Lund University, 221 00, Lund, Sweden
  • 2Department of Biology, Lund University, 223 62, Lund, Sweden
  • 3Centro de Tecnología Agroindustrial, Universidad Mayor de San Simón, Cochabamba, Bolivia

Sesquiterpene lactones (SLs) are the most characteristic bioactive constituents of Eupatorium species. They have shown to exhibit a broad variety of different biological activities, specially cytotoxic and antitumor effects1, 2. As part of our search of structurally interesting and biologically active compounds from Bolivian medicinal plants, a phytochemical investigation of Eupatorium lasiophthalmum G. has resulted in the isolation of two new eudesmanolides (1–2) and one triterpene (3) together with fourteen known SLs. The structures of the new compounds and their cytotoxicity towards five breast cancer cell lines (MCF-7, SK-BR-3, HCC1937, L56Br-C1 and JIMT-1) and one normal-like breast-derived cell line (MCF-10A) will be discussed.