Planta Med 2012; 78 - PI227
DOI: 10.1055/s-0032-1320914

Two new biphenyl-type neolignan derivatives from the flower buds of Magnolia biondii

CY Chung 1, SY Fang 2, YY Chang 2, TL Hwang 3, MI Chung 1, JJ Chen 2
  • 1Faculty of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
  • 2Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan.
  • 3Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan

The dried flower buds of Magnolia biondii Pamp (Magnoliaceae), commonly known as Xin-yi in China. The dried flower buds of M . biondii are one of the most widely used medicinal plants officially listed in the Chinese Pharmacopoeia. M. biondii are used for the treatment of nasal empyema and headache in China. Pharmacologic studies have revealed that M. biondii has platelet- activating factor (PAF) receptor antagonistic activity on isolated platelet membranes. Investigation on EtOAc-soluble fraction of flower buds of M. biondii has led to the isolation of two new biphenyl-type neolignan derivatives, 4-allyl-2-(2-(hydroxymethyl)benzofuran-5-yl)phenol (1) and 5,5'-diallyl-2'-ethoxybiphenyl-2-ol (2), along with 7 known compounds. The structure of new compound 1 and 2 were determined through spectroscopic and MS analyses. This symposium describes the structural elucidation of 1 and 2.