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DOI: 10.1055/s-0032-1320913
Sesterterpenoids and diterpenoids from the aerial parts of Scutellaria coleifolia Levl
Scutellaria plants belong to the Lamiaceae family and include about 350 species, which are known to contain bioactive diterpenoids and flavonoids.1 As part of our study for searching new drug seeds, we have investigated chemical constituents of Scutellaria coleifolia. The EtOAc-soluble fraction of the aerial parts of this plant (130g) was separated by repeated column chromatography to give fourteen new compounds, along with three known compounds. Compounds 1 and 2 were sesterterpenoids with a γ-lactone moiety, structurally similar to manoalide derivatives. Although manoalide derivatives were isolated from marine sponges2, compounds 1 and 2 appear to be the first example of this type of compounds isolated from a higher plant. The structure elucidation and biological activities of compounds 1-7 will be presented.
References
1. X. Shang et al., J. Ethnopharmacology 2010, 128, 279–313.
2. S.-J. Piao et al., J. Nat. Prod. 2011, 74, 1248–1254.