Planta Med 2012; 78 - PI214
DOI: 10.1055/s-0032-1320901

New cardenolides from Kalanchoe tubiflora (Harvey) Hamet

HC Huang 1, MK Lin 1, HL Yang 2, YH Kuo 1
  • 1School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
  • 2Department of Nutrition, China Medical University, Taichung 404, Taiwan

Two new cardenolides kalantubolide A (1), and kalantubolide B (2), three known bufadienolides (3-5), and thirteen known compounds (6-18) were isolated and characterized from the EtOH extract of Kalanchoe tubiflora (Harvey) Hamet. The structures of these cardenolides were assigned based on spectroscopic analyses that included 1D and 2D NMR techniques, such as HMQC, HMBC, and NOESY. The biological evaluation indicated that 1-5 showed cytotoxicity against four human tumor cell lines. In addition, the bufadienolides (4–6) blocked the cell cycle in the G2/M-phase and induced apoptosis in HL-60 cells.