New anti-inflammatory aromatic and triterpene components from Antrodia camphorata

Antrodia camphorata (Polyporaceae) is a parasitic fungus on the inner wall of the heartwood of Cinnamomun kanehirai.The fruiting bodies of A. camphorata are called ”jang-jy” or “niu-chang-chih” in Taiwan. Traditionally, the fungus has been used for the treatment of food and drug intoxication, diarrhea, abdominal pain, hypertension and liver cancer.The components of this fungi have showed activity of anti-inflammation, immune-modulation, anti-Helicobactor pylori, neuroprotective from Aβ damage. In this time, we present the result of chemical studies from a mixture of fruting body and mycelia of solid cultures of A. camphorata, and 4 new benzenoids, Ar 1, Ar 2, Dimer 3, Dimer 4, two new tritertenoids, T 5, and T 6 together with two known benenoids, Ar 7, and Ar 8, were isolated and elucidated. Compounds, Dimer 3, T 5, T 6, Ar 7, and Ar 8 were evaluated for anti-inflammatory activities, and exhibited the potential inhibition against LPS-induced NO production with IC₅₀ values 3.1±0.3, 5.2±0.2, 2.6±0.2, 13.3±1.3, and 3.3±0.4 µg/ml, respectively.