Planta Med 2012; 78 - PI203
DOI: 10.1055/s-0032-1320891

Antihepatitis B virus constituents from Solanum erianthum

SC Chou 1, TJ Huang 1, EH Lin 1, CH Huang 1, CH Chou 1
  • 1Research Center for Biodiversity and Graduate Institute of Ecology and Evolutionary Biology, China Medical University, Taichung 40402, Taiwan

Eleven constituents including α-linolenic acid (1), 13S-hydroxy-9(Z),11(E)-octadecadienoic acid (2), 9S-hydroxy-10(E),12(Z),15(Z)-octadectrienoic acid (3), 9(Z),11(E)-octadecadienoic acid (4), octadecanoic acid (5), loliolide (6), dihydroactinidiolide (7), solasonine (8), solamargine (9), camelliaside C (10), 5-methoxy-(3'',4''-dihydro-3'',4''-diacetoxy)-2'',2''-dimethylpyrano-(7,8:5'',6'')-flavone (11) were isolated from title plant. 9 showed the most potent activity against HBsAg (IC50: 1.57µM). 11 was the only active constituent (IC50: 36.11µM) against HBeAg. 9 revealed strong inhibition in DNA replication (IC50: 2.17µM). 1 showed prominent selected index (SI) in anti-HBsAg (7.75) and inhibition of DNA replication (7.18). This is the first report that unsaturated fatty acid 1, steroidal alkaloid glycoside 9 and flavone 11, showed excellent activity against HBV.