Planta Med 2012; 78 - PI178
DOI: 10.1055/s-0032-1320866

Cytotoxic antioxidant & antimicrobial activity of labdane type diterpene & tow flavones from Salvia sharifi Rech. & Esfan

A Rustaiyan 1, MH Farjam 2
  • 1Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • 2Department of Chemistry, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran

Salvia is a fascinating plant genus and one of the wide spread members of the Labiatae (Lamiaceae) family, which comprises about 900 herbs and shrubs, growing in the temperate and warmer zones of the world. Some of these species feature prominently in the pharmacopoeias of many countries throughout the word. The range of traditional applications of the herbs in domestic medicine seems to be endless.

Two flavones namely Ladanein and 6-hydroxy-5,7,4'-trimethoxy-flavone and one known diterpene namely ent-13-epi-manoyloxide were isolated from the ethyl acetate and methanol extracts of the lowered aerial parts of Salvia sharifi. The compounds were purified using several chromatographic methods.

Their structures were established using one and two-dimensional NMR spectroscopy and mass spectrometry.

Isolated compounds have been screened for cytotoxic, antioxidant and antimicrobial activity. The diterpene showed higher cytotoxic activity than the flavones while the later compounds were better antioxidant than the isolated diterpene.