Bioactive diterpenoids from Callicarpa longissima

YW Liu; YB Cheng; CC Liaw; CH Chen; JH Guh; TL Hwang; YC Shen

doi:10.1055/s-0032-1320864

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Planta Med 2012; 78 - PI176
DOI: 10.1055/s-0032-1320864

Bioactive diterpenoids from Callicarpa longissima

YW Liu ¹, YB Cheng ¹, CC Liaw ¹, CH Chen ¹, JH Guh ¹, TL Hwang ², YC Shen ¹

¹School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan
²Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan

Congress Abstract

Investigation of the leaves and twigs of C. longissima resulted in the isolation of four new compounds (1–4), named callilongisins A-D, and five known compounds, including (E)-6β-hydroxylabda-8(17), 13-dien-15-oic acid and artemetin. Compounds 1–3 are 3,4-seco-abietane-type diterpenoids and compound 4 is an analog of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity of against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.