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Planta Med 2012; 78 - PI174
DOI: 10.1055/s-0032-1320862
DOI: 10.1055/s-0032-1320862
Pyrrole alkaloids from the fruits of Lycium chinense and their hepatoprotective activity
Four new pyrrole alkaloids, methyl 2-(2-formyl-5-methoxymethylpyrrol-1-yl)propanoate (1), methyl 2-(2-formyl-5-methoxymethylpyrrol-1-yl)-3-(p-hydroxyphenyl)propanoate (2), dimethyl 2-(2-formyl-5-methoxymethylpyrrol-1-yl)succinate (3), and dimethyl 2-(2-formyl-5-methoxymethylpyrrol-1-yl)pentanedioate (4), were isolated from EtOAc extracts of the fruits of Lycium chinense Miller (Solanaceae). The structures of 1-4 were elucidated by analyses of various spectral data including the 1H, 13C, HSQC, and HMBC NMR spectra. Compounds 1-4 exhibited hepatoprotective activity in vitro with 86.6±7.9, 86.7±3.0, 93.1±8.3, and 97.7±3.9 cell viabilities at 1µM, respectively, in cultured HepG2 liver cell injury induced by CCl4.