Planta Med 2012; 78 - PI169
DOI: 10.1055/s-0032-1320857

New β-carboline alkaloids from Galianthe ramosa (Rubiaceae)

CS de Freitas 1, D Silva 1, L Kato 1, CMA de Oliveira 1, IT Schuquel 2, CC da Silva 2, S de O Santin 2, PG Delprete 3, BR Silva Neto 4, CMA Soares 4, M Pereira 4
  • 1Instituto de Química
  • 4Instituto de Ciências Biológicas- Universidade Federal de Goiás, Campus Samambaia, 74001–970- Goiânia, GO
  • 2Depto. Química, Universidade Estadual de Maringa, Av. Colombo, 5790, 87020–900 Maringá, PR, Brazil
  • 3Herbier de Guyane, (IRD),UMR AMAP, B.P. 165, 97323 Cayenne Cedex, French Guiana, France

Galianthe Griseb. (Rubiaceae, tribe Spermacoceae) is a genus comprising 50 endemic species in South America, its main center of diversity is located in central and southern Brazil. In our continuing chemical and biological investigations concerning Rubiaceae species from Cerrado, we report the isolation of new compounds 1 and 2, together with the known epi-catechin (3), ursolic and oleanolic acid. The alkaloid 2 inhibited the enzyme malato synthase from pathogenic fungus Paracoccidioides brasiliensis wich is considered an important target since it is not found in human.